IVF medication side effects  

Common side effects from IVF injections 

• bruising at the injection sites 

• local redness and irritation. Temporary redness can be caused by the antagonist injection. 

• a clear vaginal mucous discharge like ovulation time, due to rising oestrogen levels. 

• tiredness 

• nausea 

• breast tenderness 

• feeling emotional 

• mild headaches 

• temporary weight gain due to fluid retention.  

Progesterone and oestrogen side effects 

Some people experience headaches, breast tenderness, nausea, bloating or mild cramping.  

It is common to notice a discharge due to vaginal progesterone. 

If you are taking injectable oestrogen or progesterone, a local reaction, infection, or allergic reaction can occur.  

Rare side effects with IVF medication 

• Anaphylaxis.  Seek medical advice immediately if you notice swelling of your face, lips, throat or have trouble breathing. 

• In extremely rare cases a blood clot in the legs or lungs or stroke could occur. 

If you have any concerns about any of the medications, you should speak to your medical team.